Neuropathogenesis of persistent infection with Borna disease virus
نویسندگان
چکیده
منابع مشابه
Synaptic pathology in Borna disease virus persistent infection.
Borna disease virus (BDV) infection of newborn rats leads to a persistent infection of the brain, which is associated with behavioral and neuroanatonomical abnormalities. These disorders occur in the absence of lymphoid cell infiltrates, and BDV-induced cell damage is restricted to defined brain areas. To investigate if damage to synaptic structures anteceded neuronal loss in BDV neonatally inf...
متن کاملThe immunopathogenesis of Borna disease virus infection.
Borna disease virus (BDV) infection represents an excellent model system to study immunopathological mechanisms based on a T cell-mediated immune reaction in the central nervous system. The single-stranded RNA Borna disease virus, a member of Bornaviridae in the order of Mononegavirale, lacks cytopathogenicity both in vitro and in vivo. After experimental infection BDV causes a persistent infec...
متن کاملBorna disease virus infection impairs synaptic plasticity.
The mechanisms whereby Borna disease virus (BDV) can impair neuronal function and lead to neurobehavioral disease are not well understood. To analyze the electrophysiological properties of neurons infected with BDV, we used cultures of neurons grown on multielectrode arrays, allowing a real-time monitoring of the electrical activity across the network shaped by synaptic transmission. Although i...
متن کاملBorna disease virus and infection in humans.
Borna disease virus (BDV) is a nonsegmented, negative-, single-stranded, highly neurotropic RNA virus with noncytolytic replication in the central nervous system. This virus causes neurological and behavioral disturbances primarily in horses and sheep, in addition to a variety of other vertebrate animal species and in laboratory animal models. BDV is now gaining much of the research attention, ...
متن کاملBorna disease virus infection in young children.
Borna Disease Virus infection (BDV) is a well known animal disease. It got its name from a disease outbreak among horses around the small town ‘‘Borna’’, 26 km south-east of Leipzig in the late 19th century. The symptoms in horses have been described in detail and involve neurologic as well as mental and behavioral disorders. A long debate exists whether or not human infections do exist. Severa...
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ژورنال
عنوان ژورنال: Uirusu
سال: 2015
ISSN: 0042-6857,1884-3433
DOI: 10.2222/jsv.65.145